Welcome to Conformetrix

Conformetrix Ltd is a pre-clinical drug discovery company. Our ligand-based approach to discovery provides unique insight into hit identification and lead optimisation. It also rapidly identifies novel chemical scaffolds for drugging any therapeutic target.

How? By using the templates provided by Mother Nature herself: the natural ligands for important receptor proteins such as GPCRs and ion-channels.

The dynamic '4D-structure' of the natural polysaccharide ligand hyaluronan

Our platform technology is a set of proprietary analytical tools that accurately determines the preferred 3D-shapes of these natural ligands and the drugs that mimic them. It also quantifies the dynamic range of movement around these preferred 3D-shapes (what we call a molecules' 4D-structure). This information is key not only to understanding how drugs work but also how to quickly & efficiently improve new compounds in development.

Conformetrix is the only company in the world with this capability. The insight it provides gives Conformetrix its competitive edge: allowing us to finally realise true ligand-based drug discovery.

For more detail on how we are using these 4D-structures to realise a new paradigm in ligand-based discovery please click here.

To learn more about Conformetrix's core platform technology please follow this link.