Welcome to Conformetrix

Conformetrix offers a new platform technology that, for the first time, can rapidly determine highly accurate and biologically-relevant (aqueous) 3D and 4D structures of any small soluble molecule. Uniquely, our proprietary method quantifies experimentally the 4D conformational preference (in terms of modality, angle and libration amplitude) of each rotatable bond without recourse to electrostatics or van der Waals calculations.

Conformetrix structures can be used to advantage within existing research and development infrastructures in pharmaceutical, agrochemical, petrochemical, food additive and cosmetics industries. Our breakthrough technology has been proven with several classes of chemistry, including therapeutic molecules (ACE-inhibitors and antibiotics) and natural ligands (GPCR-binding peptides and carbohydrate molecules).

Compared to the market alternatives, Conformetrix structures have been demonstrated to reduce uncertainty in computer-aided drug design processes including docking, virtual high-throughput screening and pharmacophore development. In medicinal chemistry, quantitative data pertaining to conformational preferences of the natural ligand can be used to facilitate focussing of structurally related molecules.

One example application for Conformetrix technology is determining the 3D structure and quantifying the conformational preferences of a natural ligand for a target protein of unknown structure. This provides the solid experimental foundation required by pharmaceutical chemists (medicinal and computational) for use in target validation, lead discovery and lead optimisation processes.

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