Conformetrix Technology

Delivering biologically-relevant 3D information

Conformetrix can solve the dynamic 3D-structure of any organic molecule. This is a world-first capability, delivering key information to aid medicinal and computational chemists discover and develop new drug chemistries.

Our technology does this directly from experimental Nuclear Magnetic Resonance (NMR) data, recorded on unlabeled compound (no C13 or N15 isotopic labeling) and without recourse to electrostatics or Van der Waals calculations.

The raw NMR data is fed into our proprietary analytical software and the output is an accurate depiction of the complete 3D-dynamic behaviour of any molecule - what we call a molecule's 4D-structure. This 4D data far surpasses what can be obtained from any existing technology [more], providing the residence time of each stable conformer and the entire range of movement a molecule undergoes in free solution (see insert to right).

Importantly, for every natural ligand or drug we have tested to date, the most populated conformers have represented the bioactive conformations of those molecules. A Conformetrix 4D-structure therefore provides unparalleled insight and guidance for processes such as virtual screening, lead optimisation, QSAR and scaffold-hopping. To learn more about how Conformetrix's technology can be used to improve these processes follow this link.

Furthermore, by deriving all this information directly from ligand structures, Conformetrix's technology frees rational discovery from its previous dependence on protein-structure data: finally realising true ligand-based drug discovery.

We are also looking to collaborate with key players in the pharmaceutical industry, offering access to our technology on a straight CRO basis initially, (please see our Services for more information) but with a view to entering into longer-term collaborations once we have validated our technology platform with these partners.